Recombinant Human Glutamate Receptor 1 (AMPA subtype) protein (ab112297)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      VVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDLNKFKESGANV TGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALTYDGVKVM
    • 分子量
      37 kDa including tags
    • 領域
      201 to 300
    • タグ
      GST tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab112297 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    useful for Antibody Production and Protein Array
  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態
    Liquid
  • 備考
    useful for Antibody Production and Protein Array
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced

関連情報

  • 別名
    • GLUR 1
    • GLUR A
    • AMPA 1
    • AMPA selective glutamate receptor 1
    • AMPA-selective glutamate receptor 1
    • GluA1
    • GLUH1
    • GluR K1
    • GluR-1
    • GluR-A
    • GluR-K1
    • GLUR1
    • GLURA
    • GluRK1
    • Glutamate receptor 1
    • Glutamate receptor ionotropic
    • Glutamate receptor ionotropic AMPA 1
    • Glutamate receptor, ionotropic, AMPA 1
    • Gria1
    • GRIA1_HUMAN
    • HBGR1
    • MGC133252
    • OTTHUMP00000160643
    • OTTHUMP00000165781
    • OTTHUMP00000224241
    • OTTHUMP00000224242
    • OTTHUMP00000224243
    see all
  • 機能
    Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
  • 組織特異性
    Widely expressed in brain.
  • 配列類似性
    Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.
  • 翻訳後修飾
    Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis.
  • 細胞内局在
    Cell membrane. Endoplasmic reticulum membrane. Cell junction > synapse > postsynaptic cell membrane. Interaction with CACNG2 promotes cell surface expression.
  • Information by UniProt

画像

  • ab112297 analysed on a 12.5% SDS-PAGE stained with Coomassie Blue.

参考文献

ab112297 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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