Recombinant Human Glucokinase protein (ab119445)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q5T6J7
    • 生物種Human
    • 配列MGSSHHHHHHSSGLVPRGSHMGSHMAAPGALLVMGVSGSGKSTVGALLAS ELGWKFYDADDYHPEENRRKMGKGIPLNDQDRIPWLCNLHDILLRDVASG QRVVLACSALKKTYRDILTQGKDGVALKCEESGKEAKQAEMQLLVVHLSG SFEVISGRLLKREGHFMPPELLQSQFETLEPPAAPENFIQISVDKNVSEI IATIMETLKMK
    • 分子量23 kDa including tags
    • 領域1 to 187
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab119445 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF
  • 精製度> 95 % SDS-PAGE.
    ab119445 was purified using conventional chromatography techniques.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 20% Glycerol, 0.58% Sodium chloride

関連情報

  • 別名
    • ATP:D-hexose 6-phosphotransferase
    • FGQTL3
    • GCK
    • GK
    • GLK
    • Glucokinase
    • Hexokinase D pancreatic isozyme
    • Hexokinase type IV
    • Hexokinase-4
    • Hexokinase-D
    • HHF3
    • HK IV
    • HK4
    • HKIV
    • HXK4_HUMAN
    • HXKP
    • LGLK
    • MODY2
    see all
  • 機能Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
  • 組織特異性Isoform 1 is expressed in pancreas. Isoform 2 and isoform 3 is expressed in liver.
  • 関連疾患Defects in GCK are the cause of maturity-onset diabetes of the young type 2 (MODY2) [MIM:125851]; also shortened MODY-2. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
    Defects in GCK are the cause of familial hyperinsulinemic hypoglycemia type 3 (HHF3) [MIM:602485]; also known as persistent hyperinsulinemic hypoglycemia of infancy (PHHI) or congenital hyperinsulinism. HHF is the most common cause of persistent hypoglycemia in infancy. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur.
  • 配列類似性Belongs to the hexokinase family.
  • Information by UniProt

Recombinant Human Glucokinase protein 画像

  • 12% SDS-PAGE showing ab119445 at approximately 23.1kDa (3µg).

Recombinant Human Glucokinase protein (ab119445) 使用論文

ab119445 has not yet been referenced specifically in any publications.

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