The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
生理活性useful for Antibody Production and Protein Array
備考useful for Antibody Production and Protein Array
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.79% Tris HCl, 0.31% Glutathione Note: Glutathione is reduced
Glial fibrillary acidic protein
Intermediate filament protein
機能GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
組織特異性Expressed in cells lacking fibronectin.
関連疾患Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.
配列類似性Belongs to the intermediate filament family.
翻訳後修飾Phosphorylated by PKN1.
細胞内局在Cytoplasm. Associated with intermediate filaments.