Recombinant Human GALNT1 protein (ab117036)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q10472
    • 生物種Human
    • 配列LPAGDVLEPVQKPHEGPGEMGKPVVIPKEDQEKMKEMFKINQFNLMASEM IALNRSLPDVRLEGCKTKVYPDNLPTTSVVIV
    • 分子量35 kDa including tags
    • 領域42 to 123

特性

Our Abpromise guarantee covers the use of ab117036 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • GALNAC T1
    • GalNAc transferase 1
    • GalNAc-T1
    • GALNT 1
    • GALNT1
    • GALT1_HUMAN
    • Polypeptide GalNAc transferase 1
    • Polypeptide N acetylgalactosaminyltransferase 1
    • Polypeptide N-acetylgalactosaminyltransferase 1 soluble form
    • pp GaNTase 1
    • pp-GaNTase 1
    • Protein UDP acetylgalactosaminyltransferase 1
    • Protein-UDP acetylgalactosaminyltransferase 1
    • UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 1
    • UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 1
    • UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 1 (GalNAc T1)
    • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1
    see all
  • 機能Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7.
  • 組織特異性Widely expressed. Expressed in all tissues tested.
  • パスウェイProtein modification; protein glycosylation.
  • 配列類似性Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
    Contains 1 ricin B-type lectin domain.
  • ドメインThere are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
    The ricin B-type lectin domain directs the glycopeptide specificity. It is required in the glycopeptide specificity of enzyme activity but not for activity with naked peptide substrates, suggesting that it triggers the catalytic domain to act on GalNAc-glycopeptide substrates.
  • 細胞内局在Secreted and Golgi apparatus > Golgi stack membrane.
  • Information by UniProt

Recombinant Human GALNT1 protein 画像

  • 12.5% SDS-PAGE stained with Coomassie Blue showing ab117036 at approximately 34.65 kDa.

Recombinant Human GALNT1 protein (ab117036) 使用論文

ab117036 has not yet been referenced specifically in any publications.

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