Recombinant Human FPR1 co-expressed with Gia2, ß1 and gamma 2 protein (ab90417)

製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab90417 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Functional Studies

    SDS-PAGE

  • 製品の状態Liquid
  • 備考


    Human FPR1 exists in various isoforms, FPR-26, FPR-98 and FPR-G6, respectively. These FPR isoforms differ from each other in amino acid positions 101 (localized at the top of the third transmembrane domain), 192 (localized in the center of the second extracellular loop) and 346 (localized at the extreme C-terminus). (FPR-26: V101, N192, E346; FPR-98: L101, N192, A346; FPR-G6: V101, K192, A346). ab90417 (FPR-G6) exhibits a partial Gi-protein coupling defect relative to FPR-26.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4

関連情報

  • 別名
    • Adenylate cyclase-inhibiting G alpha protein
    • fMet-Leu-Phe receptor
    • FMLP
    • fMLP receptor
    • Formyl peptide receptor 1
    • FPR
    • GNAI2B
    • Guanine nucleotide-binding protein G(i) subunit alpha-2
    • Lipoxin A4 receptor
    • LXA4R
    • N-formyl peptide receptor
    • N-formylpeptide chemoattractant receptor
    • OTTMUSP00000024381
    see all
  • 関連性FMLP (Formyl peptide receptor 1), a Chemoattractant Receptor, mediates chemotaxis, degranulation, and superoxide production, as part of the inflammatory response. Bacterial N-formylmethionyl peptides and Annexin A1, specific ligands for FMLP, attract polymorphonuclear neutrophils to sites of infection. FMLP receptors promote the phosphorylation and downregulation of CCR5, which has been shown to inhibit HIV infection. Therefore, ligands for an FMLP receptor may be able to inhibit HIV infection. FMLP has been reported in blood monocytes, neutrophils, and phagocytes, as well as in liver, astrocytes, and microglia. ESTs have been isolated from B-cell/lung/testis, blood, brain, eye, heart, liver/spleen, kidney, lung, pancreas, placenta, spleen, and uterus libraries. The G protein family of signal transducers includes 5 heterotrimers, which are most clearly distinguished by their different alpha chains; they have virtually identical beta chains and similar gamma chains. G protein alpha inhibitor chain 2 is a subunit of the G(i) G protein, whose role is in inhibiting adenylate cyclase activity in response to bound GTP. The G proteins possess GTPase activity and are components of a complex membrane signaling system that includes membrane bound receptors. The system exists to modulate extracellular signals as they are transmitted into the cell.
  • 細胞内局在Cell membrane; Multi-pass membrane protein.

Recombinant Human FPR1 co-expressed with Gia2, ß1 and gamma 2 protein (ab90417) 使用論文

ab90417 has not yet been referenced specifically in any publications.

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