Recombinant Human Fibrillarin protein (ab99443)

製品の概要

  • 製品名
    Recombinant Human Fibrillarin protein
  • タンパク質長
    Protein fragment

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MGSSHHHHHHSSGLVPRGSHRSMGKNVMVEPHRHEGVFICRGKEDALVTK NLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKP GAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTN IIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGH FVISIKANCIDSTASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVV VGVYRPPPKVKN
    • 分子量
      29 kDa including tags
    • 領域
      83 to 321
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab99443 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF
  • 精製度
    >= 85 % SDS-PAGE.
    ab99443 is purified using conventional chromatography techniques.
  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 0.2M Sodium chloride, 20mM Tris HCl, 1mM EDTA, 1mM DTT, pH 8.0

関連情報

  • 別名
    • 34 kD nucleolar scleroderma antigen
    • 34 kDa nucleolar scleroderma antigen
    • Fbl
    • FBRL_HUMAN
    • FIB
    • FIB1
    • FLRN
    • Histone-glutamine methyltransferase
    • Nop1p
    • RNA U3 small nucleolar interacting protein 1
    • RNU3IP1
    • rRNA 2' O methyltransferase fibrillarin
    • rRNA 2'-O-methyltransferase fibrillarin
    see all
  • 機能
    S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239).
  • 配列類似性
    Belongs to the methyltransferase superfamily. Fibrillarin family.
  • 翻訳後修飾
    By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA).
  • 細胞内局在
    Nucleus, nucleolus. Fibrillar region of the nucleolus.
  • Information by UniProt

画像

  • 15% SDS-PAGE showing ab99443 at approximately 28.9kDa (3µg).

参考文献

ab99443 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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