配列の追加情報Encodes the signal peptide and extracellular domain of human FGF R4 (aa1-201) was fused to the Fc region of human IgG1 (aa 93-330). The chimeric protein was expressed in modified human 293 cells.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Shipped at 4°C. Store at +4°C.
Constituents: 10% Trehalose, 1% Human serum albumin
再構成It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.
Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
Fibroblast growth factor receptor 4
Hydroxyaryl protein kinase
Protein tyrosine kinase
Tyrosine kinase related to fibroblast growth factor receptor
機能Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19.
組織特異性Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.
配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain.
翻訳後修飾Glycosylated. Phosphorylated on tyrosine residue (By similarity). Phosphorylation requires the presence of a functional (phosphorylated) FGFR1 and not necessarily by means of FGFR heterodimerization.
Functional Studies - FGFR4 protein (Fc Chimera) (ab83999)
Densitometry of protein isoforms visualised by 2-DE.
The densitometry scan demonstrates the purified human cell expressed protein exists in multiple isoforms, which differ according to their level of post-translational
The triangle indicates the theoretical MW and pI of the protein.
Recombinant Human FGFR4 protein (Fc Chimera) (ab83999) 使用論文
has not yet been referenced specifically in any publications.