Recombinant Human FGFR4 protein (Fc Chimera) (ab83999)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来HEK 293 cells
  • アミノ酸配列
    • アクセッション番号P22455
    • 生物種Human
    • 配列Theoretical Sequence: LEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA ERGGHWYKEGSRLAPAGRVR GWRGRLEIASFLPEDAGRYLCLARGSMI VLQNLTLITGDSLTSSNDDEDPKSHRDLSNRHS YPQQAPYWTHPQRME KKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIR IPK VDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTV LHQDWLNGKEYKCRVSNKAL PAPIEKTISKAKGQPREPQVYTLPPSRD ELTKNQVSLTCLVKGFYPSDIAVEWESNGQPEN NYKTTPPVLDSDGSF FLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
    • 領域22 to 201
    • 配列の追加情報Encodes the signal peptide and extracellular domain of human FGF R4 (aa1-201) was fused to the Fc region of human IgG1 (aa 93-330). The chimeric protein was expressed in modified human 293 cells.

関連製品

特性

Our Abpromise guarantee covers the use of ab83999 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C.

    Preservative: None
    Constituents: 10% Trehalose, 1% Human serum albumin

  • 再構成It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.

関連情報

  • 別名
    • CD 334
    • CD334
    • CD334 antigen
    • fc13h 10
    • fc13h10
    • Fgfr 4
    • FGFR-4
    • Fgfr4
    • FGFR4_HUMAN
    • Fibroblast growth factor receptor 4
    • Hydroxyaryl protein kinase
    • JTK 2
    • JTK2
    • MGC20292
    • Protein tyrosine kinase
    • TKF
    • Tyrosine kinase related to fibroblast growth factor receptor
    • Tyrosylprotein kinase
    see all
  • 機能Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19.
  • 組織特異性Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.
  • 配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Glycosylated.
    Phosphorylated on tyrosine residue (By similarity). Phosphorylation requires the presence of a functional (phosphorylated) FGFR1 and not necessarily by means of FGFR heterodimerization.
  • 細胞内局在Membrane. Isoform 2 may be secreted.
  • Information by UniProt

Recombinant Human FGFR4 protein (Fc Chimera) 画像

  • Densitometry of protein isoforms visualised by 2-DE.
    The densitometry scan demonstrates the purified human cell expressed protein exists in multiple isoforms, which differ according to their level of post-translational modification.
    The triangle indicates the theoretical MW and pI of the protein.

Recombinant Human FGFR4 protein (Fc Chimera) (ab83999) 使用論文

ab83999 has not yet been referenced specifically in any publications.

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