Recombinant human FGFR1 alpha protein (Fc Chimera) (ab55758)

製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus
  • アミノ酸配列
    • アクセッション番号P11362
    • 生物種Human
    • 配列RPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGV QLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDA LPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAA KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVV PSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDK EMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTS PLYLEDPRRASIEGRGDPEEPKSCDKTHTCPPCPAPELLGGPSVFLFPPK PKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQY NSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREP QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPP VLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG K
    • 領域22 to 376
    • 配列の追加情報Fused with the Fc region of Human IgG1 at the C-terminus via a Xa cleavage site.

特性

Our Abpromise guarantee covers the use of ab55758 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性

    Determined by its ability to inhibit human FGF acidic dependent proliferation on R1 cells. The ED50 for this effect is typically at 15.0-30.0 ng/ml.

  • アプリケーション

    SDS-PAGE

  • 精製度> 90 % SDS-PAGE.
    Purity: > 90%, by SDS-PAGE and visualised by silver stain.
  • 製品の状態Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 再構成Reconstitute in PBS or medium to a concentration not lower than 50µg/ml. Soluble in water and most aqueous buffers.

関連情報

  • 別名
    • BFGFR
    • CD331
    • CEK
    • FGFBR
    • FGFR1
    • FLG
    • FLT2
    • FMS like tyrosine kinase 2
    • HBGFR
    • KAL2
    • N SAM
    • OGD
    see all
  • 関連性FGFR1 (fibroblast growth factor receptor 1) is a member of the fibroblast growth factor receptor family and contains an Ig-like domain and a tyrosine kinase domain. This receptor has multiple isoforms and is a Type I membrane protein. FGFR1 is widely expressed, with distinct isoforms expressed in specific tissues. FGFR1 binds fibroblast growth factor and induces mitogenesis and cellular differentiation. Defects in FGFR1 result in Pfeiffer syndrome associated with craniosynostosis. FGFR1 can be modified by phosphorylation and can bind basic/acidic fibroblast factor depending on the receptor isoform. FGFR1 has been shown to interact with N-cadherin and NCAM.
  • 細胞内局在Cell Membrane

Recombinant human FGFR1 alpha protein (Fc Chimera) (ab55758) 使用論文

ab55758 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us.

The protein is a dimer and has a MW of approximately 170 kD.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Use our pro...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"