製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q8NB91
    • 生物種Human
    • 配列GSENFLIDNMAFTLEKELVTLSSLSSAIAKHESNFMQRCEVSKGKSSVVA AALSDRRENIHPYRKELQREKKKMLQTNLKVSGALYREITLKVAEVQLKS DFAAQKLSN
    • 分子量38 kDa including tags
    • 領域750 to 858

特性

Our Abpromise guarantee covers the use of ab116811 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    ELISA

    SDS-PAGE

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

関連情報

  • 別名
    • FA2
    • FAAP90
    • FAAP95
    • FAB
    • FACB
    • Fancb
    • FANCB_HUMAN
    • Fanconi anemia associated polypeptide of 95 kDa
    • Fanconi anemia group B protein
    • Fanconi anemia, complementation group B
    • Fanconi anemia-associated polypeptide of 95 kDa
    • Protein FACB
    see all
  • 機能DNA repair protein required for FANCD2 ubiquitination.
  • 関連疾患Defects in FANCB are the cause of Fanconi anemia complementation group B (FANCB) [MIM:300514]. It is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
    Defects in FANCB are the cause of X-linked VACTERL-H (XVACTERL-H) [MIM:314390]; also known as X-linked VACTERL association with hydrocephalus syndrome. VACTERL is an acronym for vertebral anomalies, anal atresia, cardiac malformations, tracheoesophageal fistula, renal anomalies (urethral atresia with hydronephrosis), and limb anomalies (hexadactyly, humeral hypoplasia, radial aplasia, and proximally placed thumb). Some cases of VACTERL-H are associated with increased chromosome breakage and rearrangement.
  • 細胞内局在Nucleus.
  • Information by UniProt

Recombinant Human FANCB protein 画像

  • 12.5% SDS-PAGE showing ab116811 at approximately 37.62kDa.
    Stained with Coomassie Blue.

Recombinant Human FANCB protein (ab116811) 使用論文

ab116811 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"