製品の概要

  • 製品名Recombinant Human EYA2 protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号O00167
    • 生物種Human
    • 配列MGSSHHHHHH SSGLVPRGSH MGSMERVFVW DLDETIIIFH SLLTGTFASR YGKDTTTSVR IGLMMEEMIF NLADTHLFFN DLEDCDQIHV DDVSSDDNGQ DLSTYNFSAD GFHSSAPAAN LCLGSGVHGG VDWMRKLAFR YRRVKEMYNT YKNNVGGLIG TPKRETWLQL RAELEALTDL WLTHSLKALN LINSRPNCVN VLVTTTQLIP ALAKVLLYGL GSVFPIENIY SATKTGKESC FERIMQRFGR KAVYVVIGDG VEEEQGAKKH NMPFWRISCH ADLEALRHAL ELEYL
    • 分子量33 kDa including tags
    • 領域244 to 514
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab124581 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF
  • 精製度> 90 % SDS-PAGE.
    ab123581 is purified using conventional chromatography techniques.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 40% Glycerol, 0.88% Sodium chloride

関連情報

  • 別名
    • EAB 1
    • EAB1
    • EYA 2
    • EYA2
    • EYA2_HUMAN
    • eyes absent 2 homolog (Drosophila)
    • Eyes absent homolog 2
    • Eyes absent homolog 2 (Drosophila)
    • Translation of this uORF probably lowers the translation efficiency of EYA2
    see all
  • 機能Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. Together with SIX1 and DACH2 seem to be involved in myogenesis. May be involved in development of the eye. Interaction with GNAZ and GNAI2 prevents nuclear translocation and transcriptional activity.
  • 組織特異性Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart.
  • 配列類似性Belongs to the HAD-like hydrolase superfamily. EYA family.
  • 発生段階At the begin of fourth week of development detected in cytoplasm of somite cells. Between the sixth and eighth week of development detected in cytoplasm of limb bud cells.
  • 細胞内局在Cytoplasm. Nucleus.
  • Information by UniProt

Recombinant Human EYA2 protein 画像

  • 15% SDS-PAGE showing ab124581 (3µg).

Recombinant Human EYA2 protein (ab124581) 使用論文

ab124581 has not yet been referenced specifically in any publications.

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