Recombinant Human EXOSC5 protein (ab124595)

製品の概要

  • 製品名Recombinant Human EXOSC5 protein
  • タンパク質長Full length protein

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q9NQT4
    • 生物種Human
    • 配列MGSSHHHHHH SSGLVPRGSH MMEEETHTDA KIRAENGTGS SPRGPGCSLR HFACEQNLLS RPDGSASFLQ GDTSVLAGVY GPAEVKVSKE IFNKATLEVI LRPKIGLPGV AEKSRERLIR NTCEAVVLGT LHPRTSITVV LQVVSDAGSL LACCLNAACM ALVDAGVPMR ALFCGVACAL DSDGTLVLDP TSKQEKEARA VLTFALDSVE RKLLMSSTKG LYSDTELQQC LAAAQAASQH VFRFYRESLQ RRYSKS
    • 分子量28 kDa including tags
    • 領域1 to 235
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab124595 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF
  • 精製度> 90 % SDS-PAGE.
    ab124595 is purified using conventional chromatography techniques.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 7.40
    Constituents: 68% PBS, 0.03% DTT, 30% Glycerol, 1.17% Sodium chloride

関連情報

  • 別名
    • Chronic myelogenous leukemia tumor antigen 28
    • CML28
    • EXOS5_HUMAN
    • EXOSC 5
    • Exosc5
    • Exosome complex component rrp46
    • exosome complex exonuclease RRP46
    • Exosome component 5
    • exosome component Rrp46
    • hRrp46p
    • p12B
    • Ribosomal RNA processing protein 46
    • Ribosomal RNA processing protein 46, S. cerevisiae, homolog of
    • Ribosomal RNA-processing protein 46
    • RRP41B
    • RRP46
    • Rrp46p
    see all
  • 機能Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as anti-sense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
  • 組織特異性Highly expressed in a variety of hematopoietic and epithelial tumor cell lines, but not in normal hematopoietic tissues or other normal tissue, with the exception of testis.
  • 配列類似性Belongs to the RNase PH family.
  • 細胞内局在Nucleus > nucleolus. Cytoplasm. Nucleus.
  • Information by UniProt

Recombinant Human EXOSC5 protein 画像

  • 15% SDS-PAGE showing ab124595 (3µg).

Recombinant Human EXOSC5 protein (ab124595) 使用論文

ab124595 has not yet been referenced specifically in any publications.

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