製品の概要

  • 製品名Recombinant Human ETHE1 protein
  • タンパク質長Full length protein

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号O95571
    • 生物種Human
    • 配列MGSSHHHHHH SSGLVPRGSH MGSHMLSQRG GSGAPILLRQ MFEPVSCTFT YLLGDRESRE AVLIDPVLET APRDAQLIKE LGLRLLYAVN THCHADHITG SGLLRSLLPG CQSVISRLSG AQADLHIEDG DSIRFGRFAL ETRASPGHTP GCVTFVLNDH SMAFTGDALL IRGCGRTDFQ QGCAKTLYHS VHEKIFTLPG DCLIYPAHDY HGFTVSTVEE ERTLNPRLTL SCEEFVKIMG NLNLPKPQQI DFAVPANMRC GVQTPTA
    • 分子量29 kDa including tags
    • 領域13 to 254
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab119454 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Mass Spectrometry

    SDS-PAGE

  • 質量分析
    MALDI-TOF
  • 精製度> 90 % SDS-PAGE.

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

関連情報

  • 別名
    • Ethe1
    • ETHE1 protein, mitochondrial precursor
    • ETHE1_HUMAN
    • ethylmalonic encephalopathy 1
    • Ethylmalonic encephalopathy protein 1
    • hepatoma subtracted clone one
    • Hepatoma subtracted clone one protein
    • HSCO
    • mitochondrial
    • Protein ETHE1
    • Protein ETHE1 mitochondrial
    • YF13H12
    see all
  • 機能Probably plays an important role in metabolic homeostasis in mitochondria. May function as a nuclear-cytoplasmic shuttling protein that binds transcription factor RELA/NFKB3 in the nucleus and exports it to the cytoplasm. Suppresses p53-induced apoptosis by preventing nuclear localization of RELA.
  • 組織特異性Ubiquitously expressed.
  • 関連疾患Defects in ETHE1 are a cause of ethylmalonic encephalopathy (EE) [MIM:602473]. EE is an autosomal recessive disorder characterized by neurodevelopmental delay and regression, recurrent petechiae, acrocyanosis, diarrhea, leading to death in the first decade of life. It is also associated with persistent lactic acidemia and ethylmalonic and methylsuccinic aciduria.
  • 配列類似性Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
  • 細胞内局在Cytoplasm. Nucleus. Mitochondrion matrix. According to PubMed:12398897, it is cytoplasmic and nuclear. According to PubMed:14732903, it is found in the mitochondrial matrix.
  • Information by UniProt

Recombinant Human ETHE1 protein 画像

  • 15% SDS-PAGE analysis of ab119454 (3µg)

Recombinant Human ETHE1 protein (ab119454) 使用論文

ab119454 has not yet been referenced specifically in any publications.

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