製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q13164-2
    • 生物種Human
    • 配列PQSSMSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEE FLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREI QMDSPMLLADLPDLQDP
    • 分子量39 kDa including tags
    • 領域561 to 677

特性

Our Abpromise guarantee covers the use of ab114671 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

    ELISA

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

関連情報

  • 別名
    • Big MAP kinase 1
    • BMK 1
    • BMK 1 kinase
    • BMK-1
    • BMK1
    • BMK1 Kinase
    • EC 2.7.11.24
    • ERK 4
    • ERK 5
    • ERK-5
    • ERK4
    • ERK5
    • Extracellular signal regulated kinase 5
    • Extracellular signal-regulated kinase 5
    • MAP kinase 7
    • MAPK 7
    • MAPK7
    • Mitogen activated protein kinase 7
    • Mitogen-activated protein kinase 7
    • MK07_HUMAN
    • OTTHUMP00000065906
    • OTTHUMP00000065907
    • PRKM 7
    • PRKM7
    • PROTEIN KINASE, MITOGEN-ACTIVATED, 7
    see all
  • 機能Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways.
  • 組織特異性Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver.
  • 配列類似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
    Contains 1 protein kinase domain.
  • ドメインThe second proline-rich region may interact with actin targeting the kinase to a specific location in the cell.
    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • 翻訳後修飾Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme (By similarity). Autophosphorylated in vitro on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent.
  • 細胞内局在Cytoplasm. Nucleus. Translocates to the nucleus upon activation.
  • Information by UniProt

Recombinant Human ERK5 protein 画像

  • SDS-PAGE analysis of ab114671 on a 12.5% gel stained with Coomassie Blue.

Recombinant Human ERK5 protein (ab114671) 使用論文

ab114671 has not yet been referenced specifically in any publications.

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