製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Saccharomyces cerevisiae
  • アミノ酸配列
    • 生物種Human
    • 配列MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQ AKKLGNNC VFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVAS KTYNLKKGQTHTLEDFQR VLDVNLMGTFNVIRLVAGEMGQNEPDQGGQ RGVIINTASVAAFEGQVGQAAYSASKGG IVGMTLPIARDLAPIGIRVM TIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAE YAHLVQAIIE NPFLNGEVIRLDGAIRMQP

特性

Our Abpromise guarantee covers the use of ab88127 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 90 % SDS-PAGE.
    ab88127 was purified by affinity chromatography.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 30% Glycerol, 0.5% Triton-X-100, 50mM HEPES, 30mM Glutathione, 100mM Sodium chloride, 1mM DTT, pH 7.5

関連情報

  • 別名
    • 17 beta hydroxysteroid dehydrogenase 10
    • 17 beta hydroxysteroid dehydrogenase type 10
    • 17-beta-HSD 10
    • 17-beta-hydroxysteroid dehydrogenase 10
    • 17b HSD10
    • 3 hydroxy 2 methylbutyryl CoA dehydrogenase
    • 3 hydroxyacyl CoA dehydrogenase type 2
    • 3 hydroxyacyl CoA dehydrogenase type II
    • 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
    • 3-hydroxyacyl-CoA dehydrogenase type II
    • 3-hydroxyacyl-CoA dehydrogenase type-2
    • AB binding alcohol dehydrogenase
    • ABAD
    • Ads9
    • Amyloid beta binding polypeptide
    • Amyloid beta peptide binding alcohol dehydrogenase
    • Amyloid beta peptide binding protein
    • CAMR
    • DUPXp11.22
    • Endoplasmic Reticulum Amyloid Binding Protein
    • Endoplasmic reticulum associated amyloid beta peptide binding protein
    • Endoplasmic reticulum-associated amyloid beta-peptide-binding protein
    • ER associated amyloid beta-binding protein
    • ERAB
    • HADH 2
    • HADH2
    • HCD 2
    • HCD2
    • HCD2_HUMAN
    • Hsd17b10
    • Hydroxyacyl CoA Dehydrogenase type II
    • Hydroxyacyl Coenzyme A dehydrogenase type II
    • Hydroxysteroid (17 beta) dehydrogenase 10
    • Mental retardation X linked syndromic 11
    • MHBD
    • Mitochondrial L3 Hydroxyacyl CoA Dehydrogenase
    • Mitochondrial ribonuclease P protein 2
    • Mitochondrial RNase P protein 2
    • MRPP2
    • MRX17
    • SCHAD
    • SDR5C1
    • Short chain dehydrogenase/reductase family 5C member 1
    • Short chain L 3 hydroxyacyl CoA dehydrogenase type 2
    • Short chain type dehydrogenase/reductase XH98G2
    • Short-chain type dehydrogenase/reductase XH98G2
    • Type 10 17b HSD
    • Type 10 17beta hydroxysteroid dehydrogenase
    • Type II HADH
    • XH98G2
    see all
  • 機能Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).
  • 組織特異性Expressed in normal tissues but is overexpressed in neurons affected in AD.
  • 関連疾患Defects in HSD17B10 are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD deficiency) [MIM:300438]. MHBD deficiency leads to neurological abnormalities, including psychomotor retardation, and, in virtually all patients, loss of mental and motor skills.
    Defects in HSD17B10 are the cause of mental retardation syndromic X-linked type 10 (MRXS10) [MIM:300220]. MRXS10 is characterized by mild mental retardation, choreoathetosis and abnormal behavior.
    A chromosomal microduplication involving HSD17B10 and HUWE1 is the cause of mental retardation X-linked type 17 (MRX17) [MIM:300705]; also known as mental retardation X-linked type 31 (MRX31). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation.
  • 配列類似性Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • 細胞内局在Mitochondrion.
  • Information by UniProt

Recombinant Human ERAB protein (ab88127) 使用論文

ab88127 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"