Recombinant Human Ephrin A1 protein (ab112282)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P20827
    • 生物種Human
    • 分子量49 kDa
    • 領域1 to 205
    • タグGST tag N-Terminus

関連製品

特性

Our Abpromise guarantee covers the use of ab112282 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性useful for Antibody Production and Protein Array
  • アプリケーション

    Western blot

    Peptide Array

    ELISA

    SDS-PAGE

  • 製品の状態Liquid
  • 備考Best use within three months from the date of receipt of this protein.useful for Antibody Production and Protein Array
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Reduced glutathione

関連情報

  • 別名
    • B61
    • ECKLG
    • EFL 1
    • EFL1
    • EFNA 1
    • Efna1
    • EFNA1_HUMAN
    • EPH related receptor tyrosine kinase ligand 1
    • EPH-related receptor tyrosine kinase ligand 1
    • Ephrin-A1
    • Ephrin-A1, secreted form
    • EphrinA1
    • EPLG 1
    • EPLG1
    • Immediate early response protein B61
    • LERK 1
    • LERK-1
    • LERK1
    • Ligand of eph related kinase 1
    • OTTHUMP00000033242
    • OTTHUMP00000033271
    • secreted form
    • TNF alpha-induced protein 4
    • TNFAIP 4
    • TNFAIP4
    • Tumor necrosis factor alpha induced protein 4
    • Tumor necrosis factor alpha-induced protein 4
    see all
  • 機能Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cones.
  • 組織特異性Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).
  • 配列類似性Belongs to the ephrin family.
  • 翻訳後修飾Undergo proteolysis by a metalloprotease to give rise to a soluble monomeric form.
  • 細胞内局在Secreted and Cell membrane.
  • Information by UniProt

Recombinant Human Ephrin A1 protein 画像

  • 12.5% SDS-PAGE Stained with Coomassie Blue with recombinant protein.
  • All lanes : Anti-Ephrin A1 antibody (ab65072) at 1 µg/ml

    Lane 1 : Recombinant Human Ephrin A1 protein (ab112282) at 0.1 µg
    Lane 2 : Recombinant Human Ephrin A1 protein (ab112282) at 0.01 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Exposure time : 150 seconds

Recombinant Human Ephrin A1 protein (ab112282) 使用論文

ab112282 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"