Recombinant human Eph receptor A1 protein (ab101778)

製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus
  • アミノ酸配列
    • アクセッション番号P21709
    • 生物種Human
    • 分子量72 kDa including tags
    • 領域569 to 976

特性

Our Abpromise guarantee covers the use of ab101778 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性The Specific activity of ab101778 was determined to be 28 nmol/min/mg.
  • アプリケーション

    Western blot

    Functional Studies

  • 精製度> 90 % Densitometry.
    Purity was determined to be >90% by densitometry.
  • 製品の状態Liquid
  • 備考

    ab204877 (Poly (4:1 Glu, Tyr) peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • EPH
    • EPH receptor A1
    • EPH tyrosine kinase
    • EPH tyrosine kinase 1
    • Epha1
    • EPHA1_HUMAN
    • Ephrin receptor Eph A1
    • Ephrin type A receptor 1
    • Ephrin type-A receptor 1
    • EPHT
    • EPHT 1
    • EPHT1
    • Erythropoietin producing hepatoma amplified sequence
    • Erythropoietin-producing hepatoma receptor
    • Esk
    • hEpha1
    • MGC163163
    • Oncogene EPH
    • Soluble EPHA1 variant 1
    • Soluble EPHA1 variant 2
    • Tyrosine protein kinase receptor EPH
    • Tyrosine-protein kinase receptor EPH
    see all
  • 機能Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
  • 組織特異性Overexpressed in several carcinomas.
  • 配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
    Contains 1 Eph LBD (Eph ligand-binding) domain.
    Contains 2 fibronectin type-III domains.
    Contains 1 protein kinase domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • 翻訳後修飾Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1.
    Ubiquitinated.
  • 細胞内局在Cell membrane.
  • Information by UniProt

Recombinant human Eph receptor A1 protein 画像

  • SDS-PAGE showing ab101778 at approximately 72kDa.
  • The Specific activity of ab101778 was determined to be 28 nmol/min/mg.

Recombinant human Eph receptor A1 protein (ab101778) 使用論文

ab101778 has not yet been referenced specifically in any publications.

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