Recombinant human Endostatin protein (ab52022)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Pichia pastoris
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab52022 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Functional Studies

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.
    Greater than 98% as determined by SDS-PAGE and HPLC.
  • 製品の状態Liquid
  • 備考For long-term storage, aliquot and keep desiccated below –20degC. Avoid freeze-thaw cycles.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Endotoxin level is less than 0.1 ng/mg of Endostatin

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • Alpha 1 collagen type 18 (XVIII)(COL18A1)
    • Alpha 1 type XVIII collagen
    • Antiangiogenic agent
    • COIA1_HUMAN
    • COL15A1
    • Col18a1
    • Collagen alpha 1(XV) chain
    • Collagen alpha 1(XVIII) chain
    • Collagen alpha-1(XV) chain
    • Collagen type XV proteoglycan
    • Collagen type XVIII alpha 1
    • Collagen XV, alpha 1 polypeptide
    • Collagen, type XV, alpha 1
    • Endostatin
    • Endostatin XV
    • FLJ27325
    • FLJ34914
    • FLJ38566
    • KNO
    • KNO1
    • KS
    • MGC74745
    • Multi functional protein MFP
    • OTTHUMP00000021782
    • OTTHUMP00000115472
    • OTTHUMP00000115473
    see all
  • 機能COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.
    Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
  • 組織特異性Present in multiple organs with highest levels in liver, lung and kidney.
  • 関連疾患Defects in COL18A1 are a cause of Knobloch syndrome (KNO) [MIM:267750]. KNO is an autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.
  • 配列類似性Belongs to the multiplexin collagen family.
    Contains 1 FZ (frizzled) domain.
    Contains 1 TSP N-terminal (TSPN) domain.
  • 翻訳後修飾Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • 細胞内局在Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

Recombinant human Endostatin protein (ab52022) 使用論文

ab52022 has not yet been referenced specifically in any publications.

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