Recombinant Human Emerin protein (ab112283)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P50402
    • 生物種Human
    • 分子量54 kDa including tags
    • 領域1 to 254

特性

Our Abpromise guarantee covers the use of ab112283 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性useful for Antibody Production and Protein Array
  • アプリケーション

    Western blot

    ELISA

    Peptide Array

    SDS-PAGE

  • 製品の状態Liquid
  • 備考Best use within three months from the date of receipt of this protein.useful for Antibody Production and Protein Array
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Reduced glutathione

関連情報

  • 別名
    • EDMD
    • Emd
    • EMD_HUMAN
    • Emerin
    • Emery Dreifuss muscular dystrophy
    • STA
    see all
  • 機能Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.
  • 組織特異性Skeletal muscle, heart, colon, testis, ovary and pancreas.
  • 関連疾患Defects in EMD are the cause of Emery-Dreifuss muscular dystrophy type 1 (EDMD1) [MIM:310300]. A degenerative myopathy characterized by weakness and atrophy of muscle without involvement of the nervous system, early contractures of the elbows Achilles tendons and spine, and cardiomyopathy associated with cardiac conduction defects.
  • 配列類似性Contains 1 LEM domain.
  • 翻訳後修飾Found in four different phosphorylated forms, three of which appear to be associated with the cell cycle.
  • 細胞内局在Nucleus inner membrane. Nucleus outer membrane. Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus.
  • Information by UniProt

Recombinant Human Emerin protein 画像

  • 12.5% SDS-PAGE Stained with Coomassie Blue with proprietary tag.

Recombinant Human Emerin protein (ab112283) 使用論文

ab112283 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab112283.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"