The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
備考Protein concentration is above or equal to 0.05 mg/ml. Best used within three months from the date of receipt.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
ELAV (embryonic lethal abnormal vision Drosophila) like 4
ELAV like 4
ELAV like protein 4
ELAV-like protein 4
Embryonic lethal abnormal vision Drosophila homolog of like 4
Hu antigen D
Paraneoplastic encephalomyelitis antigen HuD
機能May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA.
配列類似性Belongs to the RRM elav family. Contains 3 RRM (RNA recognition motif) domains.
翻訳後修飾Methylation at Arg-243 by CARM1 weakens protective binding to the 3'-UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state. Methylation is inhibited by NGF, which facilitates neurite outgrowth.