製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q9GZV4
    • 生物種Human
    • 配列MGSSHHHHHHSSGLVPRGSHMADEIDFTTGDAGASSTYPMQCSALRKNGF VVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMD VPNIKRNDYQLICIQDGYLSLLTETGEVREDLKLPEGELGKEIEGKYNAG EDVQVSVMCAMSEEYAVAIKPCK
    • 分子量19 kDa including tags
    • 領域1 to 153
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab99140 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF
  • 精製度>= 85 % SDS-PAGE.
    ab99140 was purified using conventional chromatography.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, pH 8.0

関連情報

  • 別名
    • 9630038B20
    • eIF 5A 2
    • eIF 5A2
    • eIF-4D
    • eIF-5A-2
    • eIF-5A2
    • EIF5A 2
    • EIF5A2
    • eIF5AII
    • Eukaryotic initiation factor 5A isoform 2
    • Eukaryotic translation initiation factor 5A-2
    • Eukaryotic translation initiation factor 5A2
    • IF5A2_HUMAN
    see all
  • 機能mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation.
  • 組織特異性Expressed in ovarian and colorectal cancer cell lines (at protein level). Highly expressed in testis. Overexpressed in some cancer cells.
  • 配列類似性Belongs to the eIF-5A family.
  • 翻訳後修飾eIF-5A seems to be the only eukaryotic protein to have an hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).
  • 細胞内局在Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Nucleus > nuclear pore complex. Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.
  • Information by UniProt

Recombinant Human eIF5A2 protein 画像

  • 15% SDS-PAGE analysis of 3µg ab99140

Recombinant Human eIF5A2 protein (ab99140) 使用論文

ab99140 has not yet been referenced specifically in any publications.

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