製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human
    • 配列MADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGK HGHA KVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGY LSLLQDSGEV REDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAA VAIKAMAK
    • 領域1 to 154

特性

Our Abpromise guarantee covers the use of ab91910 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 製品の状態Lyophilised
  • 備考Protein Identity confirmed by Mass Spectrometry (MS/MS) (acquired on initial reference batch)
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.5% Thiourea, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5

  • 再構成Reconstitute with 67 µl aqua dest.

関連情報

  • 別名
    • eIF 4D
    • EIF 5A
    • eIF 5A 1
    • eIF 5A1
    • eIF-4D
    • eIF-5A
    • eIF-5A-1
    • eIF-5A1
    • eIF4D
    • eif5a
    • EIF5A1
    • eIF5AI
    • Eukaryotic initiation factor 5A
    • Eukaryotic initiation factor 5A isoform 1
    • Eukaryotic translation initiation factor 5A
    • Eukaryotic translation initiation factor 5A 1
    • Eukaryotic translation initiation factor 5A-1
    • IF5A1_HUMAN
    • MGC104255
    • MGC99547
    • Rev binding factor
    • Rev-binding factor
    • uORF
    • uORF A
    see all
  • 機能mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
  • 組織特異性Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level).
  • 配列類似性Belongs to the eIF-5A family.
  • 翻訳後修飾eIF-5A seems to be the only eukaryotic protein to have an hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).
  • 細胞内局在Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Nucleus > nuclear pore complex. Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.
  • Information by UniProt

Recombinant Human eIF5A protein 画像

  • The image shows an electrophoretic assay performed using an Agilent 5100 ALP. In some images coloured control bands can be seen at 15 kDa (green) and/or 240 kDa (purple). The protein-specific band is blue.

Recombinant Human eIF5A protein (ab91910) 使用論文

ab91910 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"