製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • 生物種
      Human
    • 分子量
      51 kDa including tags
    • タグ
      GST tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab56276 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Functional Studies

    SDS-PAGE

  • 精製度
    > 90 % SDS-PAGE.

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

関連情報

  • 別名
    • AUTS19
    • CBP
    • eIF 4E
    • EIF 4F
    • eIF 4F 25 kDa subunit
    • eIF-4E
    • eIF-4F 25 kDa subunit
    • eIF4E
    • EIF4E1
    • EIF4EL1
    • EIF4F
    • Eukaryotic translation initiation factor 4 E
    • Eukaryotic translation initiation factor 4E
    • Eukaryotic translation initiation factor 4E like 1
    • IF4E_HUMAN
    • Messanger RNA Cap Binding Protein eIF 4E
    • MGC111573
    • mRNA cap binding protein
    • mRNA cap-binding protein
    see all
  • 機能
    Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.
  • 配列類似性
    Belongs to the eukaryotic initiation factor 4E family.
  • 翻訳後修飾
    Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.
  • Information by UniProt

画像

  • SDS Page analysis of ab56276

参考文献

This product has been referenced in:
  • Wollenhaupt K  et al. The eIF4E repressor protein 4E-BP2 is merely truncated, despite 4E-BP1 degradation in the porcine uterine tissue during implantation. Mol Reprod Dev 79:767-76 (2012). Read more (PubMed: 22968905) »
  • Wollenhaupt K  et al. 4E-BP1 degradation and eIF4E truncation occur spatially distinctly in the porcine uterine epithelia and are features of noninvasive implantation in the pig. Mol Reprod Dev 78:895-905 (2011). Read more (PubMed: 21887718) »

See all 4 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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