製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P60228
    • 生物種Human
    • 配列MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDLLSDTNM VDFAMDVYKNLYSDDIPHALREKRTTVVAQLKQLQAETEPIVKMFEDPET TRQMQSTRDGRMLFDYLADKHGFRQEYLDTLYRYAKFQYECGNYSGAAEY LYFFRVLVPATDRNALSSLWGKLASEILMQNWDAAMEDLTRLKETIDNNS VSSPLQSLQQRTWLIHWSLFVFFNHPKGRDNIIDLFLYQPQYLNAIQTMC PHILRYLTTAVITNKDVRKRRQVLKDLVKVIQQESYTYKDPITEFVECLY VNFDFDGAQKKLRECESVLVNDFFLVACLEDFIENARLFIFETFCRIHQC ISINMLADKLNMTPEEAERWIVNLIRNARLDAKIDSKLGHVVMGNNAVSP YQQVIEKTKSLSFRSQMLAMNIEKKLNQNSRSEAPNWATQDSGFY
    • 分子量75 kDa including tags
    • 領域1 to 445

特性

Our Abpromise guarantee covers the use of ab114769 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Western blot

    ELISA

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • eIF-3 p48
    • eIF3e
    • EIF3E_HUMAN
    • EIF3S6
    • eIFe
    • Eukaryotic translation initiation factor 3 subunit 6
    • Eukaryotic translation initiation factor 3 subunit E
    • eukaryotic translation initiation factor 3, subunit 6 (48kD)
    • INT6
    • mammary tumor-associated protein INT6
    • murine mammary tumor integration site 6 (oncogene homolog)
    • Viral integration site protein INT-6 homolog
    see all
  • 機能Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
  • 組織特異性Ubiquitously expressed. Expressed at highest levels in appendix, lymph, pancreas, skeletal muscle, spleen and thymus.
  • 配列類似性Belongs to the eIF-3 subunit E family.
    Contains 1 PCI domain.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Cytoplasm. Nucleus > PML body.
  • Information by UniProt

Recombinant Human eIF3e protein 画像

  • ab114769 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human eIF3e protein (ab114769) 使用論文

ab114769 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab114769.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"