製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEK AGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQ KLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEPREADKSHPEQREL RPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSVDPDSPAEASGLRAQDRIV EVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEH LNGPL
    • 分子量
      66 kDa including tags
    • 領域
      1 to 358

特性

Our Abpromise guarantee covers the use of ab112385 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    Useful for Antibody Production and Protein Array
  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態
    Liquid
  • 備考
    ab112385 is best used within three months from the date of receipt.Useful for Antibody Production and Protein Array
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced

関連情報

  • 別名
    • EBP 50
    • EBP50
    • Ezrin radixin moesin binding phosphoprotein 50
    • Ezrin-radixin-moesin-binding phosphoprotein 50
    • Na(+)/H(+) exchange regulatory cofactor NHE RF
    • Na(+)/H(+) exchange regulatory cofactor NHE-RF1
    • Na+/H+ exchange regulatory co factor
    • NHERF
    • NHERF 1
    • NHERF-1
    • NHERF1
    • NHRF1_HUMAN
    • NPHLOP2
    • Regulatory cofactor of Na(+)/H(+) exchanger
    • Slc9a3r1
    • Sodium hydrogen exchanger regulatory factor 1
    • Sodium-hydrogen exchanger regulatory factor 1
    • Sodium/hydrogen exchanger regulatory factor 1
    • Solute carrier family 9 (sodium/hydrogen exchanger) member 3 regulator 1
    • Solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1
    • Solute carrier family 9 isoform 3 regulatory factor 1
    • Solute carrier family 9 isoform A3 regulatory factor 1
    • Solute carrier family 9 member 3 regulator 1
    see all
  • 機能
    Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Interacts with MCC.
  • 組織特異性
    Detected in liver, kidney, pancreas, prostate, spleen, small intestine and placenta, in particular in the syncytiotrophoblast.
  • 関連疾患
    Defects in SLC9A3R1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 2 (NPHLOP2) [MIM:612287]. Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization).
  • 配列類似性
    Contains 2 PDZ (DHR) domains.
  • 翻訳後修飾
    Phosphorylated on serine residues.
  • 細胞内局在
    Cytoplasm. Apical cell membrane. Endomembrane system. Cell projection > filopodium. Cell projection > ruffle. Cell projection > microvillus. Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner (By similarity). Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Found in microvilli, ruffling membrane and filopodia of HeLa cells. Present in lipid rafts of T-cells.
  • Information by UniProt

画像

  • ab112385 analysed by 12.5% SDS-PAGE and stained with Coomassie Blue.

参考文献

ab112385 has not yet been referenced specifically in any publications.

レビューと Q&A

There are currently no Customer reviews or Questions for ab112385.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録