Recombinant human Dystrophia myotonica protein kinase (ab85755)

製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • 生物種Human

関連製品

特性

Our Abpromise guarantee covers the use of ab85755 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性The Specific activity of ab85755 was determined to be 4.5 nmol/min/mg.
  • アプリケーション

    Western blot

    Functional Studies

    SDS-PAGE

  • 製品の状態Liquid
  • 備考

    ab204853 (IRS1 peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • DM
    • DM 1
    • DM kinase
    • DM protein kinase
    • DM-kinase
    • DM1
    • DM1 protein kinase
    • DM1PK
    • DMK
    • DMPK
    • DMPK_HUMAN
    • Dystrophia myotonica 1
    • Dystrophia myotonica protein kinase
    • MDPK
    • MT PK
    • MT-PK
    • Myotonic dystrophy associated protein kinase
    • Myotonic dystrophy protein kinase
    • Myotonin protein kinase
    • Myotonin protein kinase A
    • Myotonin-protein kinase
    • Thymopoietin homolog
    see all
  • 機能Critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity. Phosphorylates phospholamban.
  • 組織特異性Most isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, cerebellar cortex and pons.
  • 関連疾患Defects in DMPK are the cause of dystrophia myotonica type 1 (DM1) [MIM:160900]; also known as Steinert disease. A muscular disorder characterized by myotonia, muscle wasting in the distal extremities, cataract, hypogonadism, defective endocrine functions, male baldness and cardiac arrhythmias. Note=The causative mutation is a CTG expansion in the 3'-UTR of the DMPK gene. A length exceeding 50 CTG repeats is pathogenic, while normal individuals have 5 to 37 repeats. Intermediate alleles with 35-49 triplets are not disease-causing but show instability in intergenerational transmissions. Disease severity varies with the number of repeats: mildly affected persons have 50 to 150 repeats, patients with classic DM have 100 to 1,000 repeats, and those with congenital onset can have more than 2,000 repeats.
  • 配列類似性Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 protein kinase domain.
  • Information by UniProt

Recombinant human Dystrophia myotonica protein kinase 画像

  • The Specific activity of ab85755 was determined to be 4.5 nmol/min/mg.
  • SDS-PAGE showing ab85755 at approximately 105kDa.

Recombinant human Dystrophia myotonica protein kinase (ab85755) 使用論文

ab85755 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab85755.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"