製品の概要

法規制情報

製品の詳細

  • 由来
    Recombinant
  • 由来
    Baculovirus infected Sf9 cells
  • アミノ酸配列
    • 生物種
      Human
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab79734 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性

    Enzyme reaction is conducted in a buffer containing 50 mM HEPES (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 200 µM ATP, 0.01% Brij-35, and 2 µM substrate (SER/THR 9) at room temperature for 1 hour.

  • アプリケーション

    SDS-PAGE

    Functional Studies

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • 1810038L18Rik
    • Dual specificity tyrosine (Y) phosphorylation regulated kinase 2
    • Dual specificity tyrosine phosphorylation regulated kinase 2
    • Dual specificity tyrosine-phosphorylation-regulated kinase 2
    • DYRK2
    • DYRK2_HUMAN
    • EC 2.7.12.1
    • FLJ21217
    • FLJ21365
    see all
  • 機能
    Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.
  • 組織特異性
    Testis, after the onset of spermatogenesis.
  • 配列類似性
    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
    Contains 1 protein kinase domain.
  • 翻訳後修飾
    Phosphorylated on serine/threonine residues.
  • 細胞内局在
    Cytoplasm. Nucleus. Translocates into the nucleus following DNA damage.
  • Information by UniProt

画像

  • SDS-PAGE showing ab79734 at approximately 63.5kDa (4µg).

参考文献

ab79734 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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