製品の概要

  • 製品名Recombinant Human Dscam protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号O60469
    • 生物種Human
    • 配列KDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDH RKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRF
    • 分子量35 kDa including tags
    • 領域184 to 271

特性

Our Abpromise guarantee covers the use of ab116817 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

関連情報

  • 別名
    • CHD2
    • CHD2 42
    • CHD2 52
    • Down syndrome cell adhesion molecule
    • DSCAM
    • DSCAM_HUMAN
    • human CHD2-52 down syndrome cell adhesion molecule 2, 9
    • OTTHUMP00000109193 2
    • SD11109p
    see all
  • 機能Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38.
  • 組織特異性Primarily expressed in brain.
  • 配列類似性Contains 6 fibronectin type-III domains.
    Contains 10 Ig-like C2-type (immunoglobulin-like) domains.
  • ドメインIg-like C2-type domains 7 to 9 are sufficient for interaction with NTN1 and commissural axon outgrowth. The transmembrane domain is necessary for interaction with DCC.
  • 翻訳後修飾Phosphorylated at tyrosine residues. Phosphorylation is enhanced by netrin.
  • 細胞内局在Secreted and Cell membrane. Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons.
  • Information by UniProt

Recombinant Human Dscam protein 画像

  • 12.5% SDS-PAGE showing ab116817 at approximately 35.31kDa.
    Stained with Coomassie Blue.

Recombinant Human Dscam protein (ab116817) 使用論文

ab116817 has not yet been referenced specifically in any publications.

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