製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    HEK 293 cells
  • アミノ酸配列
    • 生物種
      Human
    • 領域
      1 to 238

特性

Our Abpromise guarantee covers the use of ab56518 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Western blot

  • 製品の状態
    Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: PBS

  • 再構成
    Reconstitute with 50 µl sterile deionized water. For long term storage or for preparation of more diluted working stock solution, a carrier protein (e.g. 1% serum albumin) should be added to the vial. After reconsitution short term store at 4 °C, for long term storage store aliquoted at - 20 °C

関連情報

  • 別名
    • Apo2
    • CD261
    • Cytotoxic TRAIL receptor
    • Death receptor 4
    • DR4
    • NF related apoptosis-inducing ligand receptor 1
    • TNF receptor superfamily member 10a
    • TNF-related apoptosis-inducing ligand receptor 1
    • TNFRSF10A
    • TR10A_HUMAN
    • TRAIL receptor 1
    • TRAIL-R1
    • TRAILR 1
    • TRAILR1
    • Tumor necrosis factor receptor superfamily member 10A
    • Tumor necrosis factor receptor superfamily member 10a variant 2
    • Tumor necrosis factor receptor superfamily, member 10a
    see all
  • 機能
    Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
  • 組織特異性
    Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.
  • 配列類似性
    Contains 1 death domain.
    Contains 3 TNFR-Cys repeats.
  • 細胞内局在
    Membrane.
  • Information by UniProt

画像

  • SDS Page analysis of ab56518; 12% separating gel; reducing conditions. Lane 1: 2 µg, Lane 2: 1 µg, Lane 3: 0.5 µg. Staining with Coomasie Blue.
  • ab56518 has a calculated molecular mass of 43 kDa. As a result of glycosylation, the recombinant protein migrates approximately as a 46 kDa protein in SDS-PAGE under reducing conditions. Immunostaining with DR4 specific antibody, detection with Goat anti-mouse / HRP secondary antibody. Gel: 12%. Lane 1 : ab56518 at 0.37 µg, Lane 2 : ab56518 at 0.15 µg, Lane 3 : ab56518 at 0.075 µg, Lane 4 : ab56518 at 0.037 µg, Lane 5 : ab56518 at 0.015 µg.

参考文献

ab56518 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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