製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q12882
    • 生物種Human
    • 配列MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCF NCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSF ITSIANKNYYGAAKMIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGPI NIGGLQQFATETLILAFSLMNHL
    • 分子量45 kDa including tags
    • 領域1 to 173

特性

Our Abpromise guarantee covers the use of ab114584 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 µg/ul. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • DHP
    • DHPDHase
    • Dihydropyrimidine dehydrogenase
    • Dihydropyrimidine dehydrogenase [NADP(+)]
    • Dihydropyrimidine dehydrogenase [NADP+]
    • Dihydrothymine dehydrogenase
    • Dihydrouracil dehydrogenase
    • DPD
    • DPYD
    • DPYD_HUMAN
    • MGC132008
    • MGC70799
    • OTTHUMP00000058954
    see all
  • 機能Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
  • 組織特異性Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.
  • パスウェイAmino-acid biosynthesis; beta-alanine biosynthesis.
  • 関連疾患Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) [MIM:274270]; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.
  • 配列類似性Belongs to the dihydropyrimidine dehydrogenase family.
    Contains 3 4Fe-4S ferredoxin-type domains.
  • 細胞内局在Cytoplasm.
  • Information by UniProt

Recombinant Human DPYD protein 画像

  • 12.5% SDS-PAGE showing ab114584 at approximately 45.03kDa stained with Coomassie Blue.

Recombinant Human DPYD protein (ab114584) 使用論文

ab114584 has not yet been referenced specifically in any publications.

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