Recombinant Human Dopamine beta Hydroxylase protein (ab114262)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      DAGFLQKYFHLINRFNNEDVCTCPQASVSQQFTSVPWNSFNRDVLKALYS FAPISMHCNKSSAVRFQGEWNLQPLPKVISTLEEPTPQCPTSQGRSPAGP TVVSIGGGKG
    • 分子量
      38 kDa including tags
    • 領域
      494 to 603

特性

Our Abpromise guarantee covers the use of ab114262 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • dbh
    • DBM
    • Dopamine beta hydroxylase
    • Dopamine beta monooxygenase
    • Dopamine beta-hydroxylase (dopamine beta-monooxygenase)
    • Dopamine beta-monooxygenase
    • DOPO_HUMAN
    • OTTHUMP00000022501
    • Soluble dopamine beta-hydroxylase
    see all
  • 機能
    Conversion of dopamine to noradrenaline.
  • パスウェイ
    Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1.
  • 関連疾患
    Defects in DBH are the cause of dopamine beta-hydroxylase deficiency (DBH deficiency) [MIM:223360]; also known as norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction.
  • 配列類似性
    Belongs to the copper type II ascorbate-dependent monooxygenase family.
    Contains 1 DOMON domain.
  • 細胞内局在
    Cytoplasmic vesicle > secretory vesicle lumen. Cytoplasmic vesicle > secretory vesicle > chromaffin granule lumen and Cytoplasmic vesicle > secretory vesicle membrane. Cytoplasmic vesicle > secretory vesicle > chromaffin granule membrane.
  • Information by UniProt

Recombinant Human Dopamine beta Hydroxylase protein 画像

  • ab114262 analysed on a 12.5% SDS-PAGE stained with Coomassie Blue.

Recombinant Human Dopamine beta Hydroxylase protein (ab114262) 使用論文

ab114262 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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