製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 分子量
      79 kDa
    • 領域
      1 to 481
    • タグ
      GST tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab112280 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    useful for Antibody Production and Protein Array
  • アプリケーション

    Western blot

    SDS-PAGE

    ELISA

    Peptide Array

  • 製品の状態
    Liquid
  • 備考
    Best use within three months from the date of receipt of this protein.useful for Antibody Production and Protein Array
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Reduced glutathione

関連情報

  • 別名
    • Docking protein 1
    • Docking protein 1 62kD
    • DOK 1
    • DOK1
    • DOK1_HUMAN
    • Downstream of tyrosine kinase 1
    • p62(dok)
    • P62DOK
    • pp62
    see all
  • 機能
    DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
  • 組織特異性
    Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells.
  • 配列類似性
    Belongs to the DOK family. Type A subfamily.
    Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • ドメイン
    The PTB domain mediates receptor interaction.
  • 翻訳後修飾
    Constitutively tyrosine-phosphorylated.
    Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway.
  • 細胞内局在
    Cytoplasm and Cytoplasm > perinuclear region.
  • Information by UniProt

画像

  • 12.5% SDS-PAGE Stained with Coomassie Blue with recombinant protein.

参考文献

ab112280 has not yet been referenced specifically in any publications.

レビューと Q&A

There are currently no Customer reviews or Questions for ab112280.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録