The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
備考Protein concentration is above or equal to 0.05 µg/ul. Best use within three months from the date of receipt of this protein.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
DnaJ (Hsp40) homolog subfamily C member 3
DnaJ homolog subfamily C member 3
double-stranded RNA-activated protein kinase inhibitor
Endoplasmic reticulum DnaJ protein 6
Interferon induced, double stranded RNA activated protein kinase inhibitor
Protein kinase inhibitor of 58 kDa
Protein kinase inhibitor p58
Protein kinase interferon inducible double stranded RNA dependent inhibitor
機能Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
組織特異性Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.