Recombinant Human DNAJB6 protein (ab105132)

製品の概要

  • 製品名
    Recombinant Human DNAJB6 protein
  • タンパク質長
    Full length protein

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      ab105132 is purified using conventional chromatography techniques.
    • 分子量
      39 kDa including tags
    • 領域
      1 to 326
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab105132 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF
  • 精製度
    > 85 % SDS-PAGE.

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 30% Glycerol, 0.2M Sodium chloride, 5mM DTT, 20mM Tris HCl, pH 8.0

関連情報

  • 別名
    • DJ4
    • DnaJ
    • DnaJ (Hsp40) homolog subfamily B member 6
    • DNAJ B6
    • DnaJ homolog subfamily B member 6
    • DnaJ like 2 protein
    • DNAJB6
    • DNJB6_HUMAN
    • Heat shock protein J2
    • HHDJ1
    • HSJ-2
    • HSJ2
    • LGMD1E
    • MRJ
    • MSJ-1
    • MSJ1
    see all
  • 機能
    Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.
  • 組織特異性
    Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus.
  • 関連疾患
    Limb-girdle muscular dystrophy 1E
  • 配列類似性
    Contains 1 J domain.
  • ドメイン
    The antiaggregation activity of isoform B resides in the serine-rich region and the C-terminus.
  • 細胞内局在
    Cytoplasm, perinuclear region. Nucleus. Cytoplasm, myofibril, sarcomere, Z line.
  • Information by UniProt

画像

  • 15% SDS-PAGE showing ab105132 (3 µg) at approximately 38.5 kDa.

参考文献

ab105132 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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