Repair polymerase. Conducts "gap-filling" DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
Belongs to the DNA polymerase type-X family.
Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity.
Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.