short chain dehydrogenase/reductase family 9C, member 4
Short chain dehydrogenase/reductase retSDR8
Short-chain dehydrogenase/reductase retSDR8
機能3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH.
組織特異性Highly expressed in trachea and epidermis. Detected at lower levels in spinal cord, bone marrow, brain, tongue, esophagus, heart, colon, testis, placenta, lung, skeletal muscle and lymph node.
配列類似性Belongs to the short-chain dehydrogenases/reductases (SDR) family.
細胞内局在Microsome membrane. Endoplasmic reticulum membrane. Associated with microsomal membranes.