製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q96FC9
    • 生物種Human
    • 配列GIFESPTGTGKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKD ESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVDR
    • 分子量36 kDa including tags
    • 領域40 to 129

特性

Our Abpromise guarantee covers the use of ab117038 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • CHL1
    • CHL1 related helicase gene 1
    • CHL1-like helicase homolog
    • CHL1-related protein 1
    • CHLR1
    • Ddx11
    • DDX11_HUMAN
    • DEAD/H (Asp Glu Ala Asp/His) box polypeptide 11
    • DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
    • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)
    • DEAD/H box
    • DEAD/H box protein 11
    • hCHLR1
    • Keratinocyte growth factor regulated gene 2 protein
    • Keratinocyte growth factor-regulated gene 2 protein
    • KRG 2
    • KRG-2
    • KRG2
    • MGC133249
    • MGC9335
    • OTTHUMP00000238778
    • OTTHUMP00000238780
    • OTTHUMP00000238784
    • OTTHUMP00000238785
    • Probable ATP dependent RNA helicase DDX11
    • Probable ATP-dependent RNA helicase DDX11
    • WABS
    see all
  • 機能DNA helicase involved in cellular proliferation. Possesses DNA-dependent ATPase and helicase activities. This helicase translocates on single-stranded DNA in the 5' to 3' direction in the presence of ATP and, to a lesser extent, dATP. Its unwinding activity requires a 5'-single-stranded region for helicase loading, since flush-ended duplex structures do not support unwinding. The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended to 500 bp by RPA or the cohesion establishment factor, the Ctf18-RFC (replication factor C) complex activities. Stimulates the flap endonuclease activity of FEN1. Required for normal sister chromatid cohesion. Required for recruitement of bovine papillomavirus type 1 regulatory protein E2 to mitotic chrmosomes and for viral genome maintenance. Required for maintaining the chromosome segregation and is essential for embryonic development and the prevention of aneuploidy. May function during either S, G2, or M phase of the cell cycle. Binds to both single- and double-stranded DNA.
  • 組織特異性Highly expressed in spleen, B-cells, thymus, testis, ovary, small intestine, and pancreas. Very low expression seen in the brain. Expressed in dividing cells and/or cells undergoing high levels of recombination. No expression is seen in cells signaled to terminally differentiate. Expressed in keratinocyte growth factor-stimulated cells but not in serum, EGF and IL1-beta-treated keratinocytes.
  • 関連疾患Defects in DDX11 are the cause of Warsaw breakage syndrome (WBRS) [MIM:613398]. It is a syndrome characterized by severe microcephaly, pre- and postnatal growth retardation, facial dysmorphism and abnormal skin pigmentation. Additional features include high arched palate, coloboma of the right optic disk, deafness, ventricular septal defect, toes and fingers abnormalities. At cellular level, drug-induced chromosomal breakage, a feature of Fanconi anemia, and sister chromatid cohesion defects, a feature of Roberts syndrome, coexist.
  • 配列類似性Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
    Contains 1 helicase ATP-binding domain.
  • 細胞内局在Nucleus. Nucleus > nucleolus. During the early stages of mitosis, localizes to condensed chromatin and is released from the chromatin with progression to metaphase. Also localizes to the spindle poles throughout mitosis and at the midbody at later stages of mitosis (metaphase to telophase). Co-localizes with bovine papillomavirus type 1 regulatory protein E2 at early stages of mitosis.
  • Information by UniProt

Recombinant Human DDX11 protein 画像

  • 12.5% SDS-PAGE stained with Coomassie Blue showing ab117038 at approximately 35.53 kDa.

Recombinant Human DDX11 protein (ab117038) 使用論文

ab117038 has not yet been referenced specifically in any publications.

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