Recombinant Human DCUN1D1 protein (ab103056)

製品の概要

  • 製品名
    Recombinant Human DCUN1D1 protein
  • タンパク質長
    Full length protein

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MGSSHHHHHHSSGLVPRGSHMNKLKSSQKDKVRQFMIFTQSSEKTAVSCL SQNDWKLDVATDNFFQNPELYIRESVKGSLDRKKLEQLYNRYKDPQDENK IGIDGIQQFCDDLALDPASISVLIIAWKFRAATQCEFSKQEFMDGMTELG CDSIEKLKAQIPKMEQELKEPGRFKDFYQFTFNFAKNPGQKGLDLEMAIA YWNLVLNGRFKFLDLWNKFLLEHHKRSIPKDTWNLLLDFSTMIADDMSNY DEEGAWPVLIDDFVEFARPQIAGTKSTTV
    • 分子量
      32 kDa including tags
    • 領域
      1 to 259
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab103056 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF
  • 精製度
    > 90 % SDS-PAGE.
    ab103056 was purified using conventional chromatography.
  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, pH 8.0

関連情報

  • 別名
    • DCN1 defective in cullin neddylation 1 domain containing 1
    • DCN1 like protein 1
    • DCNL1
    • DCUN1 domain containing protein 1
    • DCUN1L1
    • Defective in cullin neddylation protein 1 like protein 1
    • RP 42
    • RP42
    • RP42 homolog
    • SCCRO
    • SCRO
    • Squamous cell carcinoma related oncogene
    • Tes 3
    • Tes3
    see all
  • 関連性
    DCUN1D1 (DCUN1 domain-containing protein 1) contains a DUF298 domain and a UBA-like ubiquitin. Forms part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression. Defects in DCUN1D1 may be a cause of squamous cell carcinomas. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas.

画像

  • 15% SDS-PAGE (3 µg)

参考文献

ab103056 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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