Recombinant Human Cytokeratin 10 protein (ab114223)

製品の概要

  • 製品名Recombinant Human Cytokeratin 10 protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P13645
    • 生物種Human
    • 配列KELTTEIDNNIEQISSYKSEITELRRNVQALEIELQSQLALKQSLEASLA ETEGRYCVQLSQIQAQISALEEQLQ QIRAETECQNTEYQQLLDIKIRL ENEIQTYRSLLE
    • 分子量38 kDa including tags
    • 領域345 to 454

特性

Our Abpromise guarantee covers the use of ab114223 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • BCIE
    • BIE
    • CK 10
    • CK-10
    • Cytokeratin-10
    • EHK
    • K10
    • K1C10_HUMAN
    • Keratin
    • Keratin 10
    • Keratin type i cytoskeletal 10
    • Keratin type I cytoskeletal 59 kDa
    • Keratin-10
    • Keratin10
    • KPP
    • KRT10
    • type I cytoskeletal 10
    see all
  • 組織特異性Seen in all suprabasal cell layers including stratum corneum.
  • 関連疾患Defects in KRT10 are a cause of bullous congenital ichthyosiform erythroderma (BCIE) [MIM:113800]; also known as epidermolytic hyperkeratosis (EHK) or bullous erythroderma ichthyosiformis congenita of Brocq. BCIE is an autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.
    Defects in KRT10 are a cause of ichthyosis annular epidermolytic (AEI) [MIM:607602]; also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI is a skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.
  • 配列類似性Belongs to the intermediate filament family.
  • Information by UniProt

Recombinant Human Cytokeratin 10 protein 画像

  • ab114223 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human Cytokeratin 10 protein (ab114223) 使用論文

ab114223 has not yet been referenced specifically in any publications.

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