Recombinant Human Cytochrome P450 Reductase protein (ab112344)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P16435
    • 生物種Human
    • 配列MINMGDSHVDTSSTVSEAVAEEVSLFSMTDMILFSLIVGLLTYWFLFRKK KEEVPEFTKIQTLTSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANR LSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMATYGEGDPTD NAQDFYDWLQETDVDLSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGA QRIFELGLGDDDGNLEEDFITWREQFWLAVCEHFGVEATGEESSIRQYEL VVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTE RHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMS LNNLDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPS EQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDHLCEL LPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVATNWLRAK EPVGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQER AWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSR EQSHKVYVQHLLKQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIV AELGAMEHAQAVDYIKKLMTKGRYSLDVWS
    • 分子量101 kDa including tags
    • 領域1 to 680
    • タグGST tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab112344 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性useful for Antibody Production and Protein Array
  • アプリケーション

    SDS-PAGE

  • 製品の状態Liquid
  • 備考useful for Antibody Production and Protein Array
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl
    Note: Glutathione is reduced

関連情報

  • 別名
    • CPR
    • CYPOR
    • DKFZp686G04235
    • FLJ26468
    • NADPH Cytochrome P450 Reductase
    • NADPH dependent cytochrome P450 reductase
    • NADPH--cytochrome P450 reductase
    • NCPR_HUMAN
    • P450 (cytochrome) oxidoreductase
    • P450 Cytochrome Oxidoreductase
    • P450R
    • por
    see all
  • 機能This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
  • 関連疾患Defects in POR are the cause of adrenal hyperplasia variant type (AHV) [MIM:201750]; also known as Antley-Bixler syndrome-like phenotype with disordered steroidogenesis. AHV is a rare variant of congenital adrenal hyperplasia. It is an autosomal recessive disorder with apparent combined P450C17 and P450C21 deficiency. Affected girls are born with ambiguous genitalia, but their circulating androgens are low and virilization does not progress. Conversely, affected boys are sometimes born undermasculinized. Boys and girls can also present with bone malformations, in some cases resembling the pattern seen in patients with Antley-Bixler syndrome.
    Defects in POR are a cause of isolated disordered steroidogenesis (IDS) [MIM:201750].
  • 配列類似性In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
    Contains 1 FAD-binding FR-type domain.
    Contains 1 flavodoxin-like domain.
  • 細胞内局在Endoplasmic reticulum membrane. Anchored to the ER membrane by its N-terminal hydrophobic region.
  • Information by UniProt

Recombinant Human Cytochrome P450 Reductase protein 画像

  • 12.5% SDS-PAGE showing ab112344 at approximately 100.87kDa stained with Coomassie Blue.

Recombinant Human Cytochrome P450 Reductase protein (ab112344) 使用論文

ab112344 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab112344.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"