Recombinant Human Cytochrome P450 2D6 protein (ab73434)

製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • 生物種Human
    • 分子量56 kDa
    • 配列の追加情報ytochrome P450 2D6 Human Recombinant (also called liver/kidney microsomal antigen 1) produced in SF9, is a glycosylated, polypeptide chain having a molecular mass of 55,801 Dalton.

特性

Our Abpromise guarantee covers the use of ab73434 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性ab73434 reacts with autoimmune hepatitis patient sera.
  • アプリケーション

    Western blot

    ELISA

  • 製品の状態Liquid
  • 備考


    This protein is suitable for biotinylation and iodination.

    ab73434 reacts with autoimmune hepatitis patient sera.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 400mM Sodium chloride, 16mM Sodium phosphate buffer, 0.08mM Potassium iodide, pH 7.6

関連情報

  • 別名
    • CPD6
    • CYP2D
    • CYP2D6
    • CYP2D7AP
    • CYP2D7BP
    • CYP2D7P2
    • CYP2D8P2
    • CYP2DL1
    • CYPIID6
    • Cytochrome P450 DB1
    • Cytochrome P450 family 2 subfamily D polypeptide 6
    • Debrisoquine 4 hydroxylase
    • Flavoprotein linked monooxygenase
    • Microsomal monooxygenase
    • P450 DB1
    • P450C2D
    • P450DB1
    • Xenobiotic monooxygenase
    see all
  • 関連性Cytochrome P450 2D6 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Cytochrome P450 2D6 is the molecular target of autoantibodies against the "liver kidney microsomal antigen 1" (LKM 1).
  • 細胞内局在Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Recombinant Human Cytochrome P450 2D6 protein (ab73434) 使用論文

ab73434 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab73434.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"