Recombinant Human Cytochrome P450 1A2 protein (ab114370)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      ESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRF LWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNL
    • 分子量
      37 kDa including tags
    • 領域
      211 to 310

特性

Our Abpromise guarantee covers the use of ab114370 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 µg/µl.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • Aryl hydrocarbon hydroxylase
    • CP 12
    • CP12
    • CP1A2_HUMAN
    • CYP1A2
    • CYPIA2
    • Cytochrome P(3)450
    • Cytochrome P450 1A2
    • Cytochrome P450 4
    • Cytochrome P450 family 1 polypeptide 2
    • Cytochrome P450 family 1 subfamily A polypeptide 2
    • Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2
    • Cytochrome P450-P3
    • Cytochrome P4501A2
    • Dioxin inducable P3 450
    • Flavoprotein linked monooxygenase
    • Microsomal monooxygenase
    • P(3)450
    • P3 450
    • P450 4
    • P450 form 4
    • P450 P3
    • P450(PA)
    • Xenobiotic monooxygenase
    see all
  • 機能
    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
  • 組織特異性
    Liver.
  • 配列類似性
    Belongs to the cytochrome P450 family.
  • 細胞内局在
    Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt

画像

  • 12.5% SDS-PAGE wtih ab114370 at 36.63kDa stained with Coomassie Blue.

参考文献

ab114370 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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