Recombinant Human Cyclin D1 protein (ab85247)

製品の概要

  • 製品名Recombinant Human Cyclin D1 protein
  • タンパク質長Full length protein

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号NP_444284.1
    • 生物種Human
    • 配列MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQK EVLPSMRKIVATWMLEVCEE QKCEEEVFPLAMNYLDRFLSLEPVKKSR LQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQM ELLLVN KLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRKHAQTFVALCATDVKFI SNPPSMVAAGSVVA AVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPDCL RACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEE VDLACTPTDVRD VDI
    • 領域1 to 295
    • タグGST tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab85247 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5

関連情報

  • 別名
    • AI327039
    • B cell CLL/lymphoma 1
    • B cell leukemia 1
    • B cell lymphoma 1 protein
    • B-cell lymphoma 1 protein
    • BCL 1
    • BCL-1
    • BCL-1 oncogene
    • BCL1
    • BCL1 oncogene
    • ccnd1
    • CCND1/FSTL3 fusion gene, included
    • CCND1/IGHG1 fusion gene, included
    • CCND1/IGLC1 fusion gene, included
    • CCND1/PTH fusion gene, included
    • CCND1_HUMAN
    • cD1
    • Cyl 1
    • D11S287E
    • G1/S specific cyclin D1
    • G1/S-specific cyclin-D1
    • Parathyroid adenomatosis 1
    • PRAD1
    • PRAD1 oncogene
    • U21B31
    see all
  • 機能Essential for the control of the cell cycle at the G1/S (start) transition.
  • 関連疾患Note=A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL). Translocation t(11;14)(q13;q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle.
    Note=A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas. Translocation t(11;11)(q13;p15) with the parathyroid hormone (PTH) enhancer.
    Defects in CCND1 are a cause of multiple myeloma (MM) [MIM:254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving CCND1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus.
  • 配列類似性Belongs to the cyclin family. Cyclin D subfamily.
  • 翻訳後修飾Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex.
    Ubiquitinated, primarily as 'Lys-48'-linked polyubiquitination. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex containing FBXO4 and CRYAB (By similarity). Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. Ubiquitination leads to its degradation and G1 arrest. Deubiquitinated by USP2; leading to stabilize it.
  • 細胞内局在Nucleus.
  • Information by UniProt

Recombinant Human Cyclin D1 protein 画像

Recombinant Human Cyclin D1 protein (ab85247) 使用論文

ab85247 has not yet been referenced specifically in any publications.

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