Recombinant Human CYB5R3 protein (ab119468)

製品の概要

  • 製品名Recombinant Human CYB5R3 protein
  • タンパク質長Full length protein

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P00387
    • 生物種Human
    • 配列MGSSHHHHHH SSGLVPRGSH MGSHMFQRST PAITLESPDI KYPLRLIDRE IISHDTRRFR FALPSPQHIL GLPVGQHIYL SARIDGNLVV RPYTPISSDD DKGFVDLVIK VYFKDTHPKF PAGGKMSQYL ESMQIGDTIE FRGPSGLLVY QGKGKFAIRP DKKSNPIIRT VKSVGMIAGG TGITPMLQVI RAIMKDPDDH TVCHLLFANQ TEKDILLRPE LEELRNKHSA RFKLWYTLDR APEAWDYGQG FVNEEMIRDH LPPPEEEPLV LMCGPPPMIQ YACLPNLDHV GHPTERCFVF
    • 分子量34 kDa including tags
    • 領域27 to 301
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab119468 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Mass Spectrometry

    SDS-PAGE

  • 質量分析
    MALDI-TOF
  • 精製度> 95 % SDS-PAGE.
    ab119468 was purified using conventional chromatography.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT, 10% Glycerol, 0.58% Sodium chloride

関連情報

  • 別名
    • B5R
    • Cyb5r3
    • Cytochrome b5 reductase
    • Cytochrome b5 reductase 3
    • DIA1
    • Diaphorase 1
    • Diaphorase-1
    • NADH cytochrome b5 reductase 3
    • NADH-cytochrome b5 reductase 3 membrane-bound form
    • NADH-cytochrome b5 reductase 3 soluble form
    • NB5R3_HUMAN
    • OTTHUMP00000028761
    • OTTHUMP00000198435
    • OTTHUMP00000198574
    • OTTHUMP00000198662
    • OTTHUMP00000198665
    see all
  • 機能Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
  • 組織特異性Isoform 2 is expressed at late stages of erythroid maturation.
  • 関連疾患Defects in CYB5R3 are the cause of methemoglobinemia CYB5R3-related (METHB-CYB5R3) [MIM:250800]. A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia. There are two types of methemoglobinemia CYB5R3-related. In type 1, the defect affects the soluble form of the enzyme, is restricted to red blood cells, and causes well-tolerated methemoglobinemia. In type 2, the defect affects both the soluble and microsomal forms of the enzyme and is thus generalized, affecting red cells, leukocytes and all body tissues. Type 2 methemoglobinemia is associated with mental deficiency and other neurologic symptoms.
  • 配列類似性Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
    Contains 1 FAD-binding FR-type domain.
  • 細胞内局在Endoplasmic reticulum membrane. Mitochondrion outer membrane and Cytoplasm. Produces the soluble form found in erythrocytes.
  • Information by UniProt

Recombinant Human CYB5R3 protein 画像

  • 15% SDS-PAGE analysis of ab119468 (3µg)

Recombinant Human CYB5R3 protein (ab119468) 使用論文

ab119468 has not yet been referenced specifically in any publications.

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