This product is an active protein and may elicit a biological response in vivo, handle with caution.
Reconstitute in distilled water
C1q and tumor necrosis factor related protein 5
Complement C1q tumor necrosis factor related protein 5 precursor
Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. CTRP5 has been suggested to be involved in age-related macular degeneration.
Functional Studies - CTRP5 protein (ab109041)
ab109041 activates AMPK signaling pathway in rat L6
myoblasts. Differentiated rat L6 myoblasts were stimulated with control buffer or 0.5µg/ml ab109041 for
30min. The cell lysate was subjected to immunoblotting with antibodies against pAMPK and total AMPK.
has not yet been referenced specifically in any publications.