製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab60764 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Functional Studies

    SDS-PAGE

  • 製品の状態Liquid
  • 備考

    ab204877 (Poly (4:1 Glu, Tyr) peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • C SRC
    • C SRC kinase
    • C src Tyrosine Kinase
    • C-SRC kinase
    • c-src tyrosine kinase
    • CSK
    • Csk A
    • CSK_HUMAN
    • CYTOPLASMIC TYROSINE KINASE
    • EC 2.7.10.2
    • MGC112926
    • MGC117393
    • MGC154049
    • P60 Src
    • Protein tyrosine kinase CYL
    • Protein-tyrosine kinase CYL
    • Proto oncogene tyrosine protein kinase
    • Tyrosine protein kinase CSK
    • Tyrosine-protein kinase CSK
    • zgc:154049
    see all
  • 機能Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.
  • 組織特異性Expressed in lung and macrophages.
  • 配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.
  • 翻訳後修飾Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.
  • 細胞内局在Cytoplasm. Cell membrane. Mainly cytoplasmic, also present in lipid rafts.
  • Information by UniProt

Recombinant human CSK protein 画像

  • Sample Kinase Activity Plot.
  • ab60764 on SDS-PAGE, MW ~52kDa.

Recombinant human CSK protein (ab60764) 使用論文

ab60764 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"