製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q49AN0
    • 生物種Human
    • 配列VEVVTENSHTLYDLDRIIELNGQKPPLTYKRFQAIISRMELPKKPVGLVT SQQMESCRAEIQENHDETYGVPSLEELGFPTEGLGPAVWQG
    • 分子量36 kDa including tags
    • 領域141 to 231

関連製品

特性

Our Abpromise guarantee covers the use of ab114947 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • cry2
    • CRY2_HUMAN
    • Cryptochrome 2
    • cryptochrome 2 (photolyase like)
    • Cryptochrome-2
    • FLJ10332
    • growth inhibiting protein 37
    • HCRY2
    • KIAA0658
    • PHLL2
    • Photolyase like
    see all
  • 機能Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK
    NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK
    NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.
  • 組織特異性Expressed in all tissues examined including fetal brain, fibroblasts, heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Highest levels in heart and skeletal muscle.
  • 配列類似性Belongs to the DNA photolyase class-1 family.
    Contains 1 DNA photolyase domain.
  • 翻訳後修飾Phosphorylation on Ser-266 by MAPK is important for the inhibition of CLOCK-ARNTL-mediated transcriptional activity. Phosphorylation by CSKNE requires interaction with PER1 or PER2.
    Ubiquitinated by the SCF(FBXL3) and SCF(FBXL21) complex, leading to its degradation.
  • 細胞内局在Cytoplasm. Nucleus. Translocated to the nucleus through interaction with other Clock proteins such as PER2 or ARNTL.
  • Information by UniProt

Recombinant Human CRY2 protein 画像

  • 12.5% SDS-PAGE showing ab114947 at approximately 35.64kDa.
    Stained with Coomassie Blue.

Recombinant Human CRY2 protein (ab114947) 使用論文

ab114947 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"