Recombinant Human CRALBP protein (ab112349)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P12271
    • 生物種Human
    • 配列MSEGVGTFRMVPEEEQELRAQLEQLTTKDHGPVFGPCSQLPRHTLQKAKD ELNEREETREEAVRELQEMVQAQAASGEELAVAVAERVQEKDSGFFLRFI RARKFNVGRAYELLRGYVNFRLQYPELFDSLSPEAVRCTIEAGYPGVLSS RDKYGRVVMLFNIENWQSQEITFDEILQAYCFILEKLLENEETQINGFCI IENFKGFTMQQAASLRTSDLRKMVDMLQDSFPARFKAIHFIHQPWYFTTT YNVVKPFLKSKLLERVFVHGDDLSGFYQEIDENILPSDFGGTLPKYDGKA VAEQLFGPQAQAENTAF
    • 分子量61 kDa including tags
    • 領域1 to 317
    • タグGST tag N-Terminus

関連製品

特性

Our Abpromise guarantee covers the use of ab112349 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性useful for Antibody Production and Protein Array
  • アプリケーション

    SDS-PAGE

    Western blot

    ELISA

  • 製品の状態Liquid
  • 備考useful for Antibody Production and Protein Array
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl
    Note: Glutathione is reduced

関連情報

  • 別名
    • Cellular retinaldehyde binding protein
    • Cellular retinaldehyde binding protein 1
    • Cellular retinaldehyde-binding protein
    • MGC3663
    • Retinaldehyde binding protein 1
    • Retinaldehyde-binding protein 1
    • RLBP 1
    • RLBP1
    • RLBP1_HUMAN
    see all
  • 機能Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.
  • 組織特異性Retina and pineal gland. Not present in photoreceptor cells but is expressed abundantly in the adjacent retinal pigment epithelium (RPE) and in the Mueller glial cells of the retina.
  • 関連疾患Defects in RLBP1 are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:268000]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
    Defects in RLBP1 are the cause of Bothnia retinal dystrophy (BRD) [MIM:607475]; also known as Vasterbotten dystrophy. Affected individuals show night blindness from early childhood with features consistent with retinitis punctata albescens and macular degeneration.
    Defects in RLBP1 are the cause of rod-cone dystrophy Newfoundland (NFRCD) [MIM:607476]. NFRCD is a retinal dystrophy reminiscent of retinitis punctata albescens but with a substantially lower age at onset and more-rapid and distinctive progression. Rod-cone dystrophies results from initial loss of rod photoreceptors, later followed by cone photoreceptors loss.
    Defects in RLBP1 are a cause of fundus albipunctatus (FA) [MIM:136880]. FA is a rare form of stationary night blindness characterized by a delay in the regeneration of cone and rod photopigments.
  • 配列類似性Contains 1 CRAL-TRIO domain.
  • 細胞内局在Cytoplasm.
  • Information by UniProt

Recombinant Human CRALBP protein 画像

  • 12.5% SDS-PAGE showing ab112349 at approximately 60.98kDa stained with Coomassie Blue.

Recombinant Human CRALBP protein (ab112349) 使用論文

ab112349 has not yet been referenced specifically in any publications.

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