製品の概要

  • 製品名Recombinant Human COX15 protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q7KZN9
    • 生物種Human
    • 配列LTESGLSMVDWHLIKEMKPPTSQEEWEAEFQRYQQFPEFKILNHDMTLTE FKFIWYMEYSH
    • 分子量32 kDa including tags
    • 領域92 to 152

特性

Our Abpromise guarantee covers the use of ab116958 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • CEMCOX2
    • COX15
    • COX15 homolog, cytochrome c oxidase assembly protein
    • COX15, S. cerevisiae, homolog of
    • COX15_HUMAN
    • cytochrome c oxidase assembly homolog 15 (yeast)
    • Cytochrome c oxidase assembly protein COX15 homolog
    • cytochrome c oxidase subunit 15
    see all
  • 機能May be involved in the biosynthesis of heme A.
  • 組織特異性Predominantly found in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.
  • パスウェイPorphyrin metabolism; heme A biosynthesis; heme A from heme O: step 1/1.
  • 関連疾患Defects in COX15 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
    Defects in COX15 are a cause of Leigh syndrome (LS) [MIM:256000]. An early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia.
  • 配列類似性Belongs to the COX15/CtaA family.
  • 細胞内局在Mitochondrion membrane.
  • Information by UniProt

Recombinant Human COX15 protein 画像

  • 12.5% SDS-PAGE showing ab116958 at approximately 32.34kDa stained with Coomassie Blue.

Recombinant Human COX15 protein (ab116958) 使用論文

ab116958 has not yet been referenced specifically in any publications.

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