製品の概要

  • 製品名
    Recombinant Human COX15 protein
  • タンパク質長
    Protein fragment

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      LTESGLSMVDWHLIKEMKPPTSQEEWEAEFQRYQQFPEFKILNHDMTLTE FKFIWYMEYSH
    • 分子量
      32 kDa including tags
    • 領域
      92 to 152

特性

Our Abpromise guarantee covers the use of ab116958 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • CEMCOX2
    • COX15
    • COX15 homolog, cytochrome c oxidase assembly protein
    • COX15, S. cerevisiae, homolog of
    • COX15_HUMAN
    • cytochrome c oxidase assembly homolog 15 (yeast)
    • Cytochrome c oxidase assembly protein COX15 homolog
    • cytochrome c oxidase subunit 15
    see all
  • 機能
    May be involved in the biosynthesis of heme A.
  • 組織特異性
    Predominantly found in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.
  • パスウェイ
    Porphyrin metabolism; heme A biosynthesis; heme A from heme O: step 1/1.
  • 関連疾患
    Defects in COX15 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
    Defects in COX15 are a cause of Leigh syndrome (LS) [MIM:256000]. An early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia.
  • 配列類似性
    Belongs to the COX15/CtaA family.
  • 細胞内局在
    Mitochondrion membrane.
  • Information by UniProt

画像

  • 12.5% SDS-PAGE showing ab116958 at approximately 32.34kDa stained with Coomassie Blue.

参考文献

ab116958 has not yet been referenced specifically in any publications.

レビューと Q&A

There are currently no Customer reviews or Questions for ab116958.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録