Recombinant Human Corneodesmosin protein (ab114566)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q15517
    • 生物種Human
    • 配列YLVPGMTYSKGKIYPVGYFTKENPVKGSPGVPSFAAGPPISEGKYFSSNP
    • 分子量31 kDa including tags
    • 領域306 to 355

関連製品

特性

Our Abpromise guarantee covers the use of ab114566 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • AI747712
    • CDSN
    • CDSN_HUMAN
    • Corneodesmosin
    • D6S586E
    • DADB-141O4.5
    • Differentiated keratinocyte S protein
    • HTSS
    • S
    • S protein
    see all
  • 機能Important for the epidermal barrier integrity.
  • 組織特異性Exclusively expressed in skin.
  • 関連疾患Defects in CDSN are a cause of hypotrichosis simplex of the scalp (HTSS) [MIM:146520]; also known as hypotrichosis Spanish type. HTSS is an autosomal dominant form of isolated alopecia. Affected individuals have normal hair in early childhood but experience progressive loss of scalp hair beginning in the middle of the first decade and almost complete baldness by the third decade.
    Defects in CDSN are the cause of peeling skin syndrome type B (BPSS) [MIM:270300]; also known as peeling skin syndrome or deciduous skin or keratolysis exfoliativa congenita. BPSS is a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis, associated with pruritus and atopy. It is an ichthyosiform erythroderma characterized by lifelong patchy peeling of the entire skin with onset at birth or shortly thereafter. Several patients have been reported with high IgE levels.
  • 細胞内局在Secreted. Found in corneodesmosomes, the intercellular structures that are involved in desquamation.
  • Information by UniProt

Recombinant Human Corneodesmosin protein 画像

  • 12.5% SDS-PAGE Stained with Coomassie Blue

Recombinant Human Corneodesmosin protein (ab114566) 使用論文

ab114566 has not yet been referenced specifically in any publications.

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