Recombinant Human COPS8 protein (denatured) (ab113601)

製品の概要

  • 製品名
    Recombinant Human COPS8 protein (denatured)
  • タンパク質長
    Full length protein
  • 製品の詳細
    Recombinant Human COPS8 protein

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MGSSHHHHHHSSGLVPRGSHMPVAVMAESAFSFKKLLDQCENQELEAPGG IATPPVYGQLLALYLLHNDMNNARYLWKRIPPAIKSANSELGGIWSVGQR IWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFALVSQAYTSIIA DDFAAFVGLPVEEAVKGILEQGWQADSTTRMVLPRKPVAGALDVSFNKFI PLSEPAPVPPIPNEQQLARLTDYVAFLEN
    • 分子量
      25 kDa including tags
    • 領域
      1 to 209
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab113601 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度
    > 90 % SDS-PAGE.

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 10% Glycerol, 2.4% Urea, 0.32% Tris HCl

関連情報

  • 別名
    • COP9 homolog
    • COP9 signalosome complex subunit 8
    • COP9 signalosome subunit 8
    • Cops8
    • CSN8
    • CSN8_HUMAN
    • hCOP9
    • JAB1 containing signalosome subunit 8
    • JAB1-containing signalosome subunit 8
    • SGN8
    • Signalosome subunit 8
    see all
  • 機能
    Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 配列類似性
    Belongs to the CSN8 family.
    Contains 1 PCI domain.
  • 細胞内局在
    Cytoplasm. Nucleus.
  • Information by UniProt

画像

  • 15% SDS-PAGE showing ab113601 (3 µg) at approximately 25.3 kDa.

参考文献

ab113601 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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